PLA & PLGA (Specified/customized) polymers for its usage to dosage forms and medicinal implants.

Optimize the release kinetics of final drug product by choice of Poly (D, L-Lactic acid) (PLA) and/or Polylactic-co-glycolic acid (PLGA) as biodegradable controlled drug release polymers from wide range portfolio of Nomisma Healthcare. One can use customized polymer/s with the specific characteristics for the desired use.

 

Polylactic-co-glycolic acid based formulations have widely demonstrated their suitability for the sustained release of therapeutics. The United States Food and Drug Administration and the European Medicines Agency have approved several drug products that are in the market and many more are in clinical development. The reduction of side effects and the improvement of patient comfort and compliance are amongst the reasons for these formulations’ success.

 

At Nomisma, PLGA polymers are manufactured, meeting the stringent quality specifications for its effective and efficient use. We offer both small and large-scale quantities. We offer the best quality biodegradable polymers and desire to become your trustable global partner. ​

 

At Nomisma, the polymers - Polylactic-co-Glycolic acids also referred as PLGs or PLGAs, are produced by ring-opening polymerization from corresponding lactide and glycolide monomers. Their degradation properties and a long history of use in human products make PLGAs as a desirable product for drug delivery, medical device, and combination products. The Nomisma Healthcare brand has been a reliable and proven source of these products in India.

 

At Nomisma healthcare, the range of PLGA incorporates monomer compositions of Lactic acid to glycolic acid from 50:50 up to 85:15 in Poly (lactic-co-glycolic) acid. These products are offered in a range of molecular weights, as well as acid, hydroxyl and ester end groups. 

 

For various requirements of PLGAs, please feel free to contact and discuss with the technical team. Our skilled research team can do the custom synthesis as per customer’s demands with combination of physical properties by applicable modifications in polymers synthesis.  Stringent residual monomer levels i.e. below 0.2 weight % with other characteristics of polymer/s are the skills of the research team.

 

Nomisma healthcare is committed to the quality of the product by analysis of each lot for its usage in various Pharmaceuticals and medicinal fields with Certificate of Analysis (COA) which includes the tests as mentioned below.

 

  • Identification by 1H-NMR.

  • Identification by FT-IR.

  • Inherent viscosity (IV).

  • Monomer ratio by NMR.

  • End group identification by 13C NMR

  • Block length identification by 13C NMR

  • Water content by KF.

  • Glass transition temperature (Tg) by DSC.

  • Free acid content by a titrimetric analysis.

  • Residual monomer content by 1H-NMR

  • Bio burden test (total aerobes, spores, and anaerobes)

 

Contact us for the requirement of any biodegradable polymers of our portfolio/related queries…

 

Poly Lactic-co-Glycolic acid (PLGA)

 

Biodegradable polymers have played an important role in the delivery of drugs in a controlled and targeted manner. Poly Lactic-co-Glycolic acid (PLGA) has been among the most attractive polymeric candidates used to fabricate devices for drug delivery and tissue engineering applications. PLGA exhibits a wide range of erosion times, has tenable mechanical properties and most importantly, is an FDA approved polymer. Further PLGA has been extensively studied for the development of devices for controlled delivery of small molecule drugs, proteins and other macro molecules which are in research activity and in commercial use.

Polylactic acid (PLA)

Polylactic acid (PLA) is a biodegradable polymer with special properties that have been studied extensively during the last decades. Polylactic acid (PLA) is one of the most promising biopolymers used now a days and has a large number of applications in food & packaging industries, medical and pharmaceutical industries. In addition, with the extensive use of exogenous implementation of different materials in the human body for the repair of different types of soft and hard tissues in many surgeries, there was enormous need to apply natural, biodegradable, non-inflammatory and bio-compatible materials. Polylactic acid (PLA) and its co-polymer composites showed superior characters over other materials in tissue engineering applications.