Cost-effective PLGA and PLA nanoparticles for Drug formulation as nanomedicine and biodegradable orthopedic implants
Since its commencement, Nomisma Healthcare has acquired abilities and specialization with business backing to give its customers precise data and outstanding items as regards. With highly qualified experts, the Nomisma group has a brilliant conception of the complexities of the market and has firm associations with key collaborators to take the organization forward.
At Nomisma Healthcare, PLGA i.e. Poly (lactic-co-glycolic) acid and PLA i.e. Polylactic acid Nanoparticles based polymers, are manufactured at our ISO 9001-2015 certified facility, meeting the desired quality standards for its efficient & successful use.
We offer in both, the small and large scale quantities of biopolymers. We provide the best quality biodegradable polymers to become trustable global polymer suppliers, meeting the products with international pharmaceutical quality standards.
Polylactic acid and Polylactic co Glycolic acids, also referred to as PLA and PLGA, are produced by ring-opening polymerization of corresponding lactide and glycolide monomers with a specific catalyst which is nontoxic. Their degradation properties and a long history of use in human products make PLGA, a desirable product for drug delivery, medical device, and combination products. The Nomisma Healthcare brand has been a reliable and proven source of these products in India and across the globe via a new technology approach at a reasonable price.
At Nomisma healthcare, the range of PLGA incorporates monomer compositions of Lactic acid to glycolic acid like 50:50, 75:25, 85:15, 45:55, etc. in Poly (lactic-co-glycolic) acid. These products are offered in a range of molecular weights, as well as acid, hydroxyl and ester end groups.
For different prerequisites of PLGAs, it would be ideal if you don't hesitate to contact/write to us. Also, our skilled research team can do the custom synthesis as per customer’s demands by applicable modifications in polymer synthesis.
The Characterization of Polymer, to be used in complex drug formulation, is a key requirement. To fulfill this requirement considering the regulatory aspects, at Nomisma Healthcare, detailed study & analysis are done which covers the following tests.
Identification by 1H-NMR.
Identification by FT-IR.
Inherent viscosity (IV).
Monomer ratio by NMR study.
End group identification by 13C NMR
Block length identification by 13C NMR
Water content by Karl Fischer.
Glass transition temperature (Tg) by DSC.
Free acid content by a titrimetric analysis.
Residual monomer content by 1H-NMR
Bioburden test (total aerobes, spores, and anaerobes)
Poly Lactic-Co-Glycolic Acid (PLGA) as biodegradable controlled drug delivery carrier.
PLGA plays an important and Key role play when used in complex drug delivery systems and biodegradable medicinal implants.
Drug loading capacity and degradation time of implant depends on
• The ratio of lactide to glycolides.
• End group of the polymer.
• Molecular weight polymer chain.
Poly L-Lactic acid (PLLA) and Poly DL- Lactic acid (PDLLA) for biomedical devices and implants
Poly L-Lactic acid (PLLA) and Poly-DL-lactic acid (PDLLA) are used as bio-degradable products for films, screws, and pins.
The following important parameters are considered during the manufacturing of such devices.
It should be a semi-crystalline or amorphous polymer.
Molecular weight about 100 kDa to 220 kDa.
Melting point about 170 - 175°C
Glass transition temperature (TG) about 55 - 60°C
A pioneer in the Biopolymers business in India.