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Initial burst release

Initial burst release

Leuprolide acetate which is a highly active agonist of luteinizing hormone–releasing hormone (LH-RH) potently inhibits their secretion in the pituitary gland and it is useful in the treatment of hormone-dependent diseases in males and females. To eliminate the...

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Factors affecting drug release

Factors affecting drug release

The drug release from the Leuprolide acetate depot mainly depends on the hydrolysis or degradation of PLGA (Poly lactic Co Glycolic acid) polymer involving diffusion and/or erosion either from its surface or from the mass. The initial burst also depends upon the drug...

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Prostate Cancer Cure is Possible

Prostate Cancer Cure is Possible

The prostate gland is an organ in reproductive anatomy. This small gland sits directly below the bladder and plays a role in producing seminal fluid, which is a component of semen. It also plays a role in hormone production and helps regulate urine flow. Changes in...

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PLGA microspheres

PLGA microspheres

Zoladex (Goserelin acetate) and Lupron Depot (Leuprolide acetate) for the treatment of prostate cancer and breast cancer. The use of PLGA and PLA-based delivery systems have made it possible to create extended-release formulations, that can lower the frequency of dosing and lesser side effects from medications

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PLGA, a smart polymer for Drug Delivery System

PLGA, a smart polymer for Drug Delivery System

The technology to deliver the necessary ingredients to the target area and sustain the efficacy there for a long time is the medical technology called DDS(Drug Delivery System). Polylactic-co-glycolic acid (PLGA) or PLG is a copolymer of polylactic acid (PLA) and...

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